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duminică, 5 august 2012

Bullying Research Looks To Twitter

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Main Category: Psychology / Psychiatry
Also Included In: IT / Internet / E-mail
Article Date: 04 Aug 2012 - 0:00 PDT Current ratings for:
Bullying Research Looks To Twitter
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Hundreds of millions of daily posts on the social networking service Twitter are providing a new window into bullying - a tough nut to crack for researchers.

"Kids are pretty savvy about keeping bullying outside of adult supervision, and bullying victims are very reluctant to tell adults about it happening to them for a host of reasons," says Amy Bellmore, a University of Wisconsin-Madison educational psychology professor. "They don't want to look like a tattletale, or they think an adult might not do anything about it."

Yet typical bullying research methods rely on the kids - victims and bullies alike - to describe their experiences in self-reporting surveys.

"For a standard study we may get access to students from one grade in one school," Bellmore says. "And then we get a one-time shot at it. We get one data collection point in a school year from these kids. It's very labor- and time-intensive."

Time and labor doesn't mean much to a computer, though, and Bellmore and graduate students Junming Sui and Kwang-Sung Jun have been helping Jerry Zhu, a UW-Madison computer sciences professor who studies machine learning, teach computers to scour the endless feed of posts on Twitter for mentions of bullying events.

"What we found, very importantly, was that quite often the victim and the bully and even bystanders talk about a real-world bullying incident on social media," Zhu says. "The computers are seeing the aftermath, the discussion of a real-world bullying episode."

Zhu fed the Twitter-monitoring computer two sets of tweets hand-selected by Bellmore's research group.

"The computer gets a set about bullying and a set definitely not about bullying," Zhu says. "In machine learning, the algorithm reads each tweet as a short text document, and it goes about analyzing the word usage to find the important words that mark bullying events."

Sufficiently trained, the computer went to work on samples of the 250 million publicly visible messages posted on Twitter on a daily basis. It wasn't long before the machine learning approach was identifying more than 15,000 bullying-related tweets per day. The traffic ebbs and flows on a weekly schedule - more active Monday through Thursday, presumably because the school-aged subjects see less of each other on the weekends.

Volume isn't the machine learning computer's only advantage over traditional research methods. As Bellmore and Zhu stepped up its training, the computer developed an eye for the roles played by the Twitter users wrapped up in bullying events.

"We taught it ways to identify bullies, victims, accusers and defenders," Bellmore says.

As the researchers dug into the tweets selected by the computer, they identified a new role: the reporter.

"The other roles were identified in the early '90s in the bullying literature," Bellmore says. "But the reporter role is new. It's just like it sounds, a child who witnessed or found out about, but wasn't participating in, a bullying encounter. That role emerged out of studying the social media roles."

Data from social media has also thrown in the progression of time, a variable often left beyond the reach of student surveys. Bellmore and Zhu hope to follow groups of individual users through multiple bullying experiences.

"Paper surveys are not as dynamic as the social media tracks," Zhu says. "You just get one snapshot in time. You don't see the evolution of bullying events. You don't see the relationships evolving."

While the researchers are collecting data largely disconnected from the individual users, the machine learning technique could be used to identify children in need of an intervention.

"We want to add sentiment analysis, an assessment of the emotion behind a social media message, to our program," Zhu says. "The idea is that if someone is powerfully affected by the event, if they are feeling extreme anger or sadness, that's when they could be a danger to themselves or others. Those are the ones that would need immediate attention."

Using the data to show the bullied that they are not alone - the researchers have considered mapping social media mentions of bullying events - could also help children deal with their feelings.

"A way victims often make sense of their bullying is by internalizing it. They decide that there's something bad about themselves - not that these other people are jerks," Bellmore says. "When they're exposed to the idea that other people are bullied, actually it has some benefit. It doesn't completely eliminate the depression or humiliation or embarrassment they might be feeling, but it can decrease it."

New insights will help the researchers supply policy-makers with a better understanding of bullying issues, Bellmore and Zhu say, which may result in more effective prevention methods.

Future work may include tapping other social media sites. For example, China's Weibo service claims 300 million users - maybe twice Twitter's count. Other services, like Facebook, may be even richer data sources.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our psychology / psychiatry section for the latest news on this subject. The group's work was presented at the North American Chapter of the Association for Computational Linguistics conference this summer, and is on the agenda at a Beijing sentiment analysis workshop in August.
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'Bullying Research Looks To Twitter'

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joi, 15 decembrie 2011

Intestine Crucial To Function Of Immune Cells, Research Shows

Main Category: Immune System / Vaccines
Also Included In: GastroIntestinal / Gastroenterology;  Arthritis / Rheumatology;  Multiple Sclerosis
Article Date: 15 Dec 2011 - 0:00 PST

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Researchers at the University of Toronto have found an explanation for how the intestinal tract influences a key component of the immune system to prevent infection, offering a potential clue to the cause of autoimmune disorders like rheumatoid arthritis and multiple sclerosis.

"The findings shed light on the complex balance between beneficial and harmful bacteria in the gut," said Prof. Jennifer Gommerman, an Associate Professor in the Department of Immunology at U of T, whose findings were published online by the scientific journal, Nature. "There has been a long-standing mystery of how certain cells can differentiate between and attack harmful bacteria in the intestine without damaging beneficial bacteria and other necessary cells. Our research is working to solve it."

The researchers found that some B cells - a type of white blood cell that produces antibodies - acquire functions that allow them to neutralize pathogens only while spending time in the gut. Moreover, this subset of B cells is critical to health.

"When we got rid of that B-cell function, the host was unable to clear a gut pathogen and there were other negative outcomes, so it appears to be very important for the cells to adopt this function in the gut," said Prof. Gommerman, whose lab conducted the research in mice.

Textbook immunology - based mostly on research done in the spleen, lymph nodes or other sterile sites distant from gut microbes - has suggested that B cells develop a specific immune function and rigidly maintain that identity. Over the last few years, however, some labs have shown the microbe-rich environment of the gut can induce flexibility in immune cell identity.

Prof. Gommerman and her colleagues, including trainees from her lab Drs. Jörg Fritz, Olga Rojas and Doug McCarthy, found that as B cells differentiate into plasma cells in the gut, they adopt characteristics of innate immune cells - despite their traditional association with the adaptive immune system. Specifically, they begin to look and act like inflammatory cells called monocytes, while maintaining their ability to produce a key antibody called Immunoglobulin A.

"What intrigued us was that this theme - B cells behaving like monocytes - had been seen before in fish and in vitro. But now we have a living example in a mammalian system, where this kind of bipotentiality is realized," said Prof. Gommerman.

This B-cell plasticity provides a potential explanation how cells dedicated to controlling pathogens can respond to a large burden of harmful bacteria without damaging beneficial bacteria and other cells essential for proper function of the intestine.

It also may explain how scientists had failed to appreciate the multi-functionality of some B cells. "There are classical markers immunologists use to identify B cells - receptors that are displayed on their surface - and most of them are absent from plasma cells," said Prof. Gommerman. "So in some cases, what people thought was a monocyte could have been a plasma cell because it had changed its surface identity, although monocytes play an important role in innate immunity as well."

This transformational ability, the researchers also found, is dependent on bacteria called commensal microflora that digests food and provides nutrients. That relationship highlights the importance of the gut in fighting infection, and begs the question of whether plasma cells trained in the gut to secrete specific anti-microbial molecules can play a role in other infectious disease scenarios, such as food-borne listeria infection.

It also opens a line of investigation into whether a systemic relationship exists between those anti-microbial molecules and healthy cells in sites remote from the intestine. Understanding the nature of that relationship could improve understanding of inflammatory mechanisms in autoimmune disorders such as lupus, rheumatoid arthritis and multiple sclerosis, in which immune cells attack and eventually destroy healthy tissue.

But the next step, said Prof. Gommerman, is to look at human samples for the same type of multi-potentiality they saw in rodent plasma cells that acquired their anti-microbial properties in the gut.

"We're really at the early stages of understanding what we call the microbiome in the gut," said Prof. Gommerman. "There is a role for plasma cells in many autoimmune diseases, and B cells can do a lot more than just make antibodies. We need to understand the full spectrum of their effects within the immune response."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our immune system / vaccines section for the latest news on this subject. The study was funded by the Canadian Institutes of Health Research, the Canada Foundation for Innovation, the Ontario Research Fund, the Austrian Academy of Sciences and the National Institutes of Health.
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luni, 12 decembrie 2011

New Research Finding Presented At American Society Of Hematology Annual Meeting

Main Category: Lymphoma / Leukemia / Myeloma
Also Included In: Lymphology/Lymphedema;  Stem Cell Research
Article Date: 12 Dec 2011 - 1:00 PST

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Researchers from Seidman Cancer Center at University Hospitals (UH) Case Medical Center and Case Western Reserve University School of Medicine presented new research findings in 25 presentations at the 53rd Annual Meeting of the American Society of Hematology (ASH) at the San Diego Convention Center.

"The breadth and depth of this innovative cancer research presented at ASH is truly outstanding," says Stan Gerson, MD, Director of the Seidman Cancer Center at UH Case Medical Center and the Case Comprehensive Cancer Center at Case Western Reserve University. "Our faculty members are making tremendous advances in hematology and oncology which is reflected in their being chosen for oral and poster presentations."

Speaking at the ASH "Scientific Symposium on Lymphoid Neoplasia" in a session titled "Autophagy and Metabolism in Lymphoid Malignancies," Clark Distelhorst, MD, provided a synthesis of the latest research indicating that autophagy occurs in lymphoid malignancies and may be a novel therapeutic target for lymphoma and other lymphoid neoplasia. His research suggests that targeting autophagy (a process through which cells eat parts of themselves to generate sufficient energy to stay alive) may be a useful adjunct to the longstanding use of glucocorticoids, such as prednisone, to kill cancer cells.

His session outlined the growing body of evidence that treatments aimed at inducing autophagy have great promise in treating lymphoid malignancies. In his session, Dr. Distelhorst presented important data explaining how glucocorticoids starve tumor cells of glucose and thus induce autophagy. Researchers at UH Case Medical Center and Case Western Reserve University identified the Dexamethasone-induced Gene 2 (dig2) that encodes a protein mediator of autophagy.

"This new cancer-fighting strategy lays the groundwork for further development of autophagy inhibitors to enhance the glucocorticoids properties," says Dr. Distelhorst, who is vice-chair of the ASH subcommittee on Lymphoid Neoplasia. "This is a major step forward in our research efforts to develop new therapies for lymphoid malignancies."

Dr. Distelhorst's session was Saturday, December 10, 4 p.m. - 5:30 p.m. in Room 6A. (San Diego Convention Center). http://ash.confex.com/ash/2011/webprogram/Paper35836.html

In a poster presentation (Abstract# 1907), Jeffery Auletta, MD, Kenneth Cooke, MD, and colleagues presented significant findings that mesenchymal stem cells (MSCs) effectively treat graft-versus-host disease (GvHD) while not interfering with bone marrow transplant's efficacy in treating leukemia.

MSCs are non-hematopoietic (not blood-forming cells) adult stem cells found in the bone marrow and were discovered at UH Seidman Cancer Center and Case Western Reserve University. They maintain hematopoietic stem cell (blood-forming cells) development and also differentiate into fat cells, bone cells and cartilage cells. MSCs have been shown to suppress immune responses ex vivo (outside the body in cell culture conditions).

Due to these properties, MSCs have been used to treat GvHD in bone marrow transplant (BMT) patients. However, how MSC immunomodulation works in vivo (inside the body) has not been well studied, and, in fact, could potentially promote leukemia/lymphoma recurrence in transplant patients. That is, the benefit of BMT is that the donor graft kills residual leukemia in the transplant recipient (host), a process called graft-versus-leukemia (GvL).

"We used a pre-clinical mouse model of BMT to study how human MSCs mediate in vivo immune effects," says Dr. Auletta. "Our results show for the first time using an animal model that human MSCs simultaneously attenuate GvHD, but spare GvL activity."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our lymphoma / leukemia / myeloma section for the latest news on this subject. The poster titled "Human Mesenchymal Stem Cells Attenuate Graft-Versus-Host Disease and Maintain Graft-Versus-Leukemia in Murine Allogeneic Bone Marrow Transplantation" was Saturday, December 10, 5:30 p.m.-7:30 p.m. in Hall GH (San Diego Convention Center). http://ash.confex.com/ash/2011/webprogram/Paper39108.html
Co-authors are Saada Eid, BS, Matthew Keller, BS, Leland Metheny, MD, Rocio Guardia-Wolff, BS, Zhenghong Lee, PhD, and Luis A. Solchaga, PhD.
Other presentations of note include:
Abstract # 1987: "Prophylaxis of Acute Gvhd Using Stromal Cell Therapy: Preliminary Results After Administration of Single or Multiple Doses of Multistem® in a Phase I Trial"
Oral and Poster Abstracts: Clinical Allogeneic Transplantation - Acute and Chronic GVHD, Immune Reconstitution: Poster I
Saturday, December 10, 5:30 p.m.-7:30 p.m. Hall GH (San Diego Convention Center)
http://ash.confex.com/ash/2011/webprogram/Paper43928.html
Authors: Richard T. Maziarz, MD, Timothy deVos, MD, Carlos Bachier, MD, Steven C. Goldstein, MD, Jose Leis, MD, PhD, Robert Perry, BS, Robert Deans, PhD, Wouter J. Van't Hof, PhD and Hillard Lazarus, MD
Abstract# 2019: "BEP Versus BEAM Conditioning for Autologous Hematopoietic Cell Transplantation in Relapsed Lymphoma. A Single Center Retrospective Review of Two Contemporaneous Cohorts"
Oral and Poster Abstracts: Clinical Allogeneic and Autologous Transplantation-Results: Poster I
Saturday, December 10, 5:30 p.m. -7:30 p.m. Hall GH (San Diego Convention Center)
http://ash.confex.com/ash/2011/webprogram/Paper38633.html
Authors: Paolo F. Caimi, MD, Ashley Rosko, MD, Pingfu Fu, PhD, Huda S. Salman, MD, Tamila L. Kindwall-Keller, DO, Brenda W. Cooper, MD and Hillard M. Lazarus, MD FACP
Abstract# 2568: "The Impact of Obesity on the Presentation & Outcome of Adult Acute Myeloid Leukemia (AML) - ECOG Studies E1900 & E3999"
Oral and Poster Abstracts: Acute Myeloid Leukemia - Biology and Pathophysiology: Poster II
Sunday, December 11, 6 p.m. -8 p.m. Hall GH (San Diego Convention Center)
http://ash.confex.com/ash/2011/webprogram/Paper38139.html
Authors: James M. Foran, MD, FRCPC, Zhuoxin Sun, PhD, Hugo F. Fernandez, MD, Larry D. Cripe, MD, Rhett P. Ketterling, MD, Janis Racevskis, PhD, Selina M. Luger, MD, Elisabeth Paietta, PhD, Hillard M. Lazarus, MD, FACP, Mark R. Litzow, MD and Martin S. Tallman, MD
Abstract# 700: "Over-Expression of the Mas Receptor Decreases Arterial Thrombosis Risk in B2R KO Mice by Elevating NO and Prostacyclin and Reducing GPVI Activation"
Oral and Poster Abstracts: Vascular Wall Biology, Endothelial Progenitor Cells and Platelet Adhesion: Endothelial Receptors and Signalling
Monday, December 12, 5:15 p.m. Marriott Hall 4 (San Diego Marriott Marquis & Marina)
http://ash.confex.com/ash/2011/webprogram/Paper41833.html
Authors: Chao Fang, Evi Stavrou, MD, Alec A. Schmaier, PhD, Gregory N. Adams, Marvin T. Nieman, PhD, Gretchen LaRusch, Matthew Bilodeau, MD, PhD, Fakhri Mahdi, Mark Warnock and Alvin H. Schmaier, MD
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duminică, 11 decembrie 2011

Research Raises New Questions About Animal Empathy

Main Category: Veterinary
Also Included In: Psychology / Psychiatry
Article Date: 11 Dec 2011 - 0:00 PST

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The emotions of rats and mice and the mental infrastructure behind them promise to illuminate the nature of human emotions, including empathy and nurturance, a Washington State University neuroscientist writes in this Friday's issue of the journal Science.

Jaak Panksepp, Baily Endowed Chair of Animal Well-Being Science and a professor of Veterinary and Comparative Anatomy, Pharmacy and Physiology, makes his case in a Perspectives column responding to research in which rats helped other rats with no explicit rewards at stake. The research, Panksepp writes, "raises questions about the affective experiences of animals other than humans."

Panksepp, who has pioneered work in how core emotions stem from deep, ancient parts of the brain, said there remains a good deal of resistance in the scientific community towards the notion that "nonhuman animals have affective experiences, and that these can and should be studied in empirical ways."

But he argues that recent advances in neuroscience are letting researchers look at how animal affect, or emotions, control learning, memory and behavior.

"Simplified models of empathy, as in mice and rats, offer new inroads for understanding our own social-emotional nature and nurture," he writes. "Such knowledge may eventually help us promote nurturant behaviors in humans."

Panksepp elaborated on his essay in a recent correspondence with the Washington State University News Center:

Q: Humans are under the impression that they are the animal with the greatest feelings and certainly have the greatest capacity to empathize with other creatures. Is this a mistaken assumption? Why?

Panksepp: There is no question that all other animals have emotional feelings. The science is strong for that. And all our strongest basic emotional feelings come from brain networks all mammals share. Unfortunately, currently we can't scientifically compare the intensity or greatness of feelings across species.

However, because we have a greater capacity to think than most, we can do more with our emotions than other animals. We can write music. Create poetry. And because of our higher mental abilities, we also have greater capacities for both empathy among strangers and cruelty. There are hints that across modern history empathy has been winning out over cruelty. But then one looks at the 20th century and wonders.

Still, the only way that empathy will continue to grow is if our higher mind gets in touch with the better angels of our lower minds - with maternal care and social joy being among the most important.

Q: If I read you correctly, the logic of attributing empathy to other, lower order animals grows out of the way our brain reflects our evolution, with higher order thinking and feeling on the more recently evolved outer layers but key, core emotions lying deep in the center. So while an animal may have a more rudimentary brain, its brain still has core functions that can include empathy. Right?

Panksepp: Indeed, we mammals share the basic tools for feeling and learning and perhaps even thinking. And empathy is reflected at all these levels. But our capacity for empathy would probably collapse without the basic emotions we share with other mammals.

Emotional contagion, a primitive form of empathic feelings, seems universal among mammals. Thinking about what others are thinking about and feeling seems much more developed in us than any other creature, except perhaps those with brains as big and complex as ours, like dolphins. Indeed, dolphins have certain brain areas that are more enlarged than ours - higher emotional regions of the brain that probably are needed for higher forms of empathy and positive fellow feelings.

Q: Why are people resisting the notion that nonhumans can have affective experiences? Panksepp: I don't think animal lovers have much doubt about the fact that animals have emotional feelings. Many scientists have little more than doubts. Thus, science has not yet reached agreement on how to study the many kinds of basic feelings we have, and that many other animals surely have.

It is clear that when we finally understand their emotions, we will begin to have lasting scientific knowledge about our own. Only modern brain science can give us answers to questions such as, 'What are emotions?' and 'What are affective feelings?' It is clear that we can have many types of affective experiences - feeling good (positive) and bad (negative) in various ways. Certain positive and negative feelings are aroused by our sensory channels, like various forms of pain and taste. Others arise from inside our bodies, like hunger and thirst signals to the brain. And then there are emotional feelings that arise largely from complex networks that reside completely within our brains, but which move our bodies intensely in various ways.

These last kinds of feelings are most important for understanding our moods and psychiatric disorders. We now have a great deal of knowledge about which brain systems generate various basic emotional feelings - experiences like desire, anger, fear, lust, motherly love, grief and playfulness. Once we understand the brain chemistries that control these kinds of emotional feelings in animals, we will better understand ourselves, as well as develop much better medicines for human emotional problems.

Q: You have a zinger of an ending. If we better understand the affective processes of mouse and rat brains, we might be better able to help humans be more nurturing. I read it this way: Humans may have the greatest capacity for compassion and empathy on earth, owing in part to our consciousness, but at times we behave worse than rats. If we understand the core, instinctual capacity for empathy among all animals, we might be better humans in the humanistic sense.

Panksepp: Yes, I think the more we know about the emotions of other animals, the more we will understand our own emotions. Without the ancient emotional systems that all mammals share, our ability to be conscious is drastically impaired. The more we know about our animal emotions, which support the rest of our mental apparatus, the more ideas we will have about how to be better people. As we follow the old philosophical advice to, "know thyself," the more options we will have for being good to others and the world.

But until quite recently, an enormous gap in our knowledge has been any solid scientific knowledge about our emotional nature. Neuroscience is changing that. And when we really know ourselves, we will be able to think about ourselves more clearly as creatures of the world. What we do with this knowledge will vary from one mind to another. My hope is that our desire to care about others will grow. To do that well is one of the best ways to take care of yourself... and the world.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our veterinary section for the latest news on this subject. Please use one of the following formats to cite this article in your essay, paper or report:

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Binge Drinking By Freshman Women Tied To Sexual Assault Risk, According To New Research

Main Category: Alcohol / Addiction / Illegal Drugs
Also Included In: Women's Health / Gynecology
Article Date: 11 Dec 2011 - 0:00 PST

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Many young women who steer clear of alcohol while they're in high school may change their ways once they go off to college. And those who take up binge drinking may be at relatively high risk of sexual assault, according to a University at Buffalo-led study in the January issue of the Journal of Studies on Alcohol and Drugs.

The college years are famously associated with drinking. But little has been known about how young women change their high school drinking habits once they start college.

So for the new study, the research team followed 437 young women from high school graduation through freshman year of college. They found that of women who had never drank heavily in high school (if at all), nearly half admitted to heavy episodic drinking -- commonly called binge drinking -- at least once by the end of their first college semester. Young women who were already engaging in binge drinking in high school continued drinking at similar levels in college.

What's more, binge drinking was linked to students' risk of sexual victimization -- regardless of what their drinking habits had been in high school.

Of all young women whose biggest binge had included four to six drinks, one quarter said they'd been sexually victimized in the fall semester. That included anything from unwanted sexual contact to rape.

And the more alcohol those binges involved, the greater the likelihood of sexual assault. Of women who'd ever consumed 10 or more drinks in a sitting since starting college, 59 percent were sexually victimized by the end of their first semester. Though young women are not to blame for being victimized -- that fault lies squarely with the perpetrator -- if colleges can make more headway in reducing heavy drinking, they may be able to prevent more sexual assaults in the process.

"This suggests that drinking-prevention efforts should begin before college," said lead researcher Maria Testa, a senior scientist at UB's Research Institute on Addictions.

The study also underscores the fact that even kids who don't drink in high school are at risk of heavy drinking once they head off to college, Testa said.

For parents, the bottom line is to talk with your kids about drinking before they go to college -- whatever you think their drinking habits have been in high school, according to Testa. And after they've left for college, keep talking. "Parents still do have an impact on their kids after they go to college," Testa said. "Parenting is not over."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
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posted by Michelle Petersen on 11 Dec 2011 at 1:27 am

So in effect if a female is binge drinking she is more likely to be sexually assaulted by those waiting to take advantage of the situation. How unbelievably irresponsible for such a forward thinking medical site. As scientist and journalists we should be asking why there are gentlemen who only show their true colours when they feel the subject is vunerable, less likely to remember and less likely to fight back. Shouldn't this article be placing the onus on those that carry out these attacks rather than those on the recieving end. Linking binge drinking with sexual assault is a short term fix. If you want to write about the dangers of binge-drinking why not follow these young binge-drinkers into alcoholism in later life or study the loss of grey matter and brain cells or the addictive personality. Or we could concentrate on the perpetrators and ask why they do this in the first place?, are they just sexually assaulting women or both sexes in a dominance play? Why do they wait until someone is vunerable? Do they feel sexual assault is acceptable and if so why? So many different angles with this article and you choose the most offensive one.....

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