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marți, 13 decembrie 2011

Dana-Farber Offers Healthy Holiday Recipes And Food Tips To Fight Cancer With Your Fork This Holiday Season

Main Category: Cancer / Oncology
Article Date: 13 Dec 2011 - 1:00 PST

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The holidays are in full swing and festive food is everywhere. Some are naughty, some are nice, and some may even help fight cancer.

"While these so-called holiday foods are delicious to eat, they can also have the added bonus of containing cancer-preventing nutrients," says Stephanie Meyers, MS, RD/LDN, a nutritionist at Dana-Farber Cancer Institute in Boston. Meyers and her colleagues have put together a list of foods and recipes that definitely belong on the "good" list this holiday season.

Go nuts

Dust off that family nutcracker. Recent research finds that walnuts may help to prevent kidney and colon cancers. In addition, the study suggests that walnuts are a rich source of antioxidants that may help protect cells from oxidative damage. Walnuts contain essential fatty acids, or the so-called "good fats," which are known to help reduce blood pressure and boost the immune system. So go nuts with this simple pesto recipe.

It's not just for pie

Pumpkin is a holiday staple for many families. It is also one of the tastiest ways to enhance the body's own natural cancer-fighting ability, notes Meyers. Pumpkins are packed with nutrients called carotenoids, which have been linked to the prevention of colon, prostate, breast, and lung cancer.

Although many people only eat pumpkin when it is made into a pie, it can also be enjoyed in a variety of other ways, including roasted pumpkin, pumpkin soup and these high-fiber pumpkin muffins.

It's the bright color that gives pumpkins their rich nutrients, so look for other orange vegetables, like sweet potatoes, carrots and butternut and acorn squash. All are also high in carotenoids.

"It is more beneficial to consume carotenoids from whole foods rather than from supplements, because carotenoids in pill form do not appear to have the same protective properties," explains Meyers. In fact, that is true of many of the nutrients in foods. Eating whole foods typically provides greater health benefits than taking a dietary supplement.

An apple a day

Apples are another food packed with cancer-preventing properties, thanks to the nutrient quercitin, which protects DNA in the body's cells from damage that could lead to the development of cancer. Recent research suggests the carbohydrates in apples may help prevent colorectal cancer development as well. To get the most protection against cancer from apples,eat them with the skin on and not combined with sugar and fats, like in a pie.

Not just for the holidays

Meyers reminds her patients at Dana-Farber that cranberries aren't just for the holidays and encourages them to eat the berries year-round. Cranberries contain benzoic acid, which has been shown to inhibit the growth of lung cancer, colon cancer, and some forms of leukemia.

She recommends buying bags of fresh cranberries now, while they are in season and at their nutritional peak, and popping them in the freezer for later use. This will help ensure that the berries will provide the highest level of cancer protection whenever they're used.

Positively pomegranate

Pomegranates are everywhere, from drinks to desserts, and there is good reason why. Recent research suggests that drinking pomegranate juice may be a delicious way to help prevent prostate cancer, as well as prevent the metastasis and spread of prostate cancer cells.

Try combining pomegranates and apples for a delicious, good-for-you dessert that is layered with flavonoids, vitamin C, and other antioxidants that can help lower the risk of cancer.

Color your world

The overall key to finding cancer-fighting foods is to look for a lot of color. In the winter, root vegetables like carrots, parsnips and beets can add a burst of color and taste. The brighter and richer the pigment, the higher the level of nutrients. "You want to load up your plate with as much colorful plant-based foods as you can," explains Meyers. "Eating a plant-based diet is the best way to help lower your risk of cancer all year long."

Article adapted by Medical News Today from original press release. Source: Dana-Farber Cancer Institute
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luni, 12 decembrie 2011

Bed Bugs Inbreed And Still Produce Healthy Offspring

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Main Category: Public Health
Also Included In: Biology / Biochemistry
Article Date: 12 Dec 2011 - 7:00 PST

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A study on how bed bug's can survive genetic inbreeding was presented at the annual meeting of the American Society of Tropical Medicine and Hygiene (ASTMH). The study offers new insights into the rapidly growing problem of bed bugs across the U.S. and worldwide. In the U.S., in the 1950s the common bed bug (Cimex lectularius) almost entirely disappeared. However, over the past decade they have made an enormous comeback. These stubborn blood-sucking bugs have developed a resistance to the insecticides (pyrethroids), which used to be extremely effective in controlling them.

In addition, the researchers at ASTMA offered to ways to control infestations in homes and apartment buildings: including new information on chemical compounds involved in attracting and repelling these insects, as well as a new method for preventing resistance to insecticide.

Although bed bugs do not transmit disease, their bites trigger allergic reactions, such as severe itching and inflamed welts (red bump, ridge or swelling of unbroken skin). These parasites pose both a social and economic hazzard to owners and residents of apartment buildings, as well as hotels and public buildings. The financial impact of bed bug control has been significant.

Rajeev Vaidyanathan, PhD, associate director of Vector Biology and Zoonotic Disease at SRI International, explained:

"New York City alone spends between $10 million and $40 million per year on bed bug control, and these numbers are repeated in other major cities across the US. Over 95 percent of pest control agencies reported bed bugs as a priority in 2010, thus superseding termites as the number one urban pest."

In hotel rooms, single family homes, and multi-unit housing, the number of reported infestations has risen 10 to 100 times more than the number of reports recorded in 1990. Nobody is completely sure why there has been such an explosion in reported occurrences.

One factor that seems to contribute to their effective infestation is their ability to produce healthy young through inbreeding, meaning only a few bed bugs are needed to produce infestations.

Coby Schal, PhD, and Ed Vargo, PhD, both entomologists at North Carolina State University (NCSU), and colleagues conducted two investigations currently under peer-review that analyzed the genetics of these pests from three multi-story apartment buildings in New Jersey and North Carolina. The researchers found in each apartment there were high levels of inbreeding, and that genetic diversity was very low, suggesting that only one or two bed bugs are needed in order for an infestation to occur. The ability to be able to produce healthy offspring through inbreeding allows these bugs to expand the infestation to other apartments within the building without any outside help.

This same conclusion was reached in another study carried out by Schal and Vargo, who examined 21 infestations from Maine to Florida - in almost all of the infestations, just a single room within the home was found to be the source.

Schal stated:

"Inbreeding gives bed bugs an advantage in being able to colonize. A single female that has been mated is able to colonize and start a new infestation. Her progeny and brothers and sisters can then mate with each other, exponentially expanding the population. With many organisms, extensive inbreeding would cause serious mutations that would eventually bring about an end to the population."

Schal adds that cockroach's also have the ability to survive inbreeding too.

According to latest research, bed bugs have become increasingly resistant to insecticides that had previously been effective. The study demonstrates that it is possible to "shut down" the mechanism that eventually leads to resistance to pyrethroid insecticides.

Ken Haynes, PhD, and team at the University of Kentucky have focused on bed bug resistance to insecticide for the last five years. The team, which included Subba Reddy Palli and Fang Zhu, decided to target specific enzymes within the pests that are connected with the P450 detoxification systems that break down the insecticides before they reach their molecular target in order to find a method that could eliminate resistance. Instead of trying to eliminate all the enzymes in the system, they used RNA interference against an enzymatic partner of the P450 family in order to turn off selective systems inside the bugs, and preserve the utility of deltamethrin (insecticide).

According to the researchers if they are able to understand and identify the function of chemical compounds secreted by the bed bugs they may be able to discover addition options for controlling bed bug populations. At present the team discovering novel compounds that influence the behavior of bed bugs. Recently, Vaidyanathan's team were able to isolated 7 new compounds that had never been identified from bed bugs that may serve as bed bug attractants. The team explained that it may be possible to create a trap with a "cocktail" of these compounds in order to attract the bed bugs.

Mark Feldlaufer, PhD, an entomologist with the US Department of Agriculture's Agricultural Research Service, is investigation further the underlying mechanisms of the chemical factors, or pheromones that influence the behavior of bed bugs. Feldlaufer has analyzed the chemical layout of "alarm compounds," which lets animals of the same species know danger is present. These alarm compounds could be used as "dispersants" during a chemical treatment, thereby exposing more pests to the treatment.

Furthermore, Feldlaufer's investigation has discovered the chemicals connected with the outer skeleton of bed bugs. Feldlaufer's is not focusing if there is any role of these chemicals in the ability of dogs to sniff out these pests. Pest control experts use dogs that are properly trained and handled in order to find bed bugs just as dogs are used to find explosives, drugs or lost individuals.

Vaidyanathan, explains "Bed bugs are our oldest roommates. There is even evidence of bed bugs in Pharaonic Egypt."

The researchers state that numbers factors have contributed to the most recent resurgence of bed bugs in the U.S..

Vaidyanathan said:

"The problems we are seeing with bed bugs in North America did not happen overnight. They are the consequence of multiple repeated introductions from all over the world. We have the highest concentration in the history of our species of humans living in cities. For as long as we've been standing on two legs, we've lived in rural areas. Over the last ten years, the majority of humans have moved to urban areas. This is the perfect setting for creating a high density of mammal nests for bed bugs. Bed bugs do not have wings; they are nest parasites, so our own population density has helped them to thrive."

Although low genetic diversity within individual infestations was observed, the NCSU team discovered that along the East cost there is a high genetic diversity across infestations as the bed bugs are most likely coming from abroad of several other different places within the US.

Prior investigations verify that one of the biggest indicators for the presence of these pests is turnover of residents. In addition one of the primary factors powering infestations is the increase in domestic and international travel.

According to Vaidyanathan bed bugs feed on chickens, and industrial production of poultry offers the optimal breeding ground for bed bugs. However, the team also state that increased introduction of second hand furniture in household items into homes also contributes to the spread.

At present, heat treatments or insecticide are used in order to control these infestations. The team highlight that insecticides readily available to the general public have generally not be tested against bed bugs. Heat treatment involves heating the entire home, or heating all furniture and belonging in a box at a high temperature for 1 hour, however both insecticides and heat treatments are costly and are not optimal for chronic infestations. The team call for enhanced education, improving current techniques for detection, as well as safe and more effective control methods.

Peter J. Hotez, MD, PhD, president of ASTMH, said:

"Just as with other global diseases once thought under control and then neglected, bed bugs have shown the ability to resurge in great numbers once our vigilance wanes. To stay one step ahead of bed bugs and other parasitic organisms, we need to sustain investment in research for new tools."

Written by: Petra Rattue

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