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vineri, 9 decembrie 2011

Racial, Ethnic And Insurance Disparities Revealed In Post-Hospital Care After Trauma

Main Category: Public Health
Also Included In: Rehabilitation / Physical Therapy
Article Date: 09 Dec 2011 - 1:00 PST

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According to the results of a new study published in the Journal of the American College of Surgeons, African-Americans, Hispanics and uninsured patients use fewer post-hospitalization services after traumatic injury, including home health care, skilled nursing care, and rehabilitation.

Notably, the authors found African-American patients fell short of post-hospital care in only a few categories, while disparities were highest among the Hispanic population. The study found Hispanic patients were far less likely to utilize post-hospitalization facilities and services regardless of insurance status, and therefore could have more severe long-term health consequences compared with other populations. This disparity could be due to a number of factors, including language barriers, provider or institutional bias, fear of the medical system, or fear of legal repercussions due to immigration status.

"Population disparities in health care have long been recognized, but this study is aimed at helping us comprehend the underlying mechanisms that lead to unequal outcomes among injured patients and demonstrates that race, ethnicity, and insurance status do indeed have important associations with post-hospital care after traumatic injury," said Adil Haider, MD, MPH, FACS, senior author of the study and associate professor of surgery, anesthesiology and critical care medicine, and co-director, Center for Surgery Trials and Outcomes Research, Johns Hopkins University School of Medicine, Baltimore.

The study examined 2007 data in the National Trauma Data Bank (NTDB) for trauma patients between the ages of 18 and 64. Of the 136,239 patients who met inclusion criteria, more African-American patients (80.5 percent) and Hispanics (86.2 percent) were discharged to home than white patients (76.8 percent). Fewer African-American patients (3.2 percent) and Hispanic patients (3.1 percent) were discharged to rehabilitation facilities than white patients (6.0 percent), and Hispanics were less likely to be discharged to home health care and nursing facilities than whites (African-American patients and white patients had similar rates for these services).

Researchers also found notable disparities in care based on insurance status. Hispanic patients were discharged at lower rates to all post-hospital care facilities regardless of whether they had private insurance, public insurance or if they were uninsured, compared with privately insured, non-Hispanic white patients. In addition, privately insured African-American patients were less likely than privately insured white patients to be discharged to home health care specifically.

Each year, trauma accounts for 37 million emergency department visits and more than two million hospital admissions in the U.S.1, and causes 31 percent of all life years lost - more than cancer, heart disease, and HIV combined.2 Rehabilitation after traumatic injury is a fundamental part of the U.S. trauma system and essential for patients to regain functionality, independence, productivity, and an acceptable quality of life. Worse outcomes have been reported in studies of trauma patients who represent disadvantaged populations. Hispanic patients with traumatic brain injury (TBI), for example, are more likely to be severely disabled six months after injury;3 Hispanic patients with spinal cord injury are more likely to be unemployed one year after injury;4 and African-American children have worse functional outcomes after TBI, including speech, locomotion, and feeding impairments.5 Several studies have also indicated uninsured patients have higher mortality rates after trauma.6 7

This study used a retrospective analysis of patient information from 2007 collected by the National Trauma Data Bank (NTDB), which is operated by the American College of Surgeons and which receives information from more than 700 trauma centers and other hospitals around the country. The year 2007 was chosen because it was the first year that the NTDB used the National Trauma Data Standard, a uniform set of trauma registry variables and definitions developed by the NTDB Committee with the U.S. Health Resources and Services Administration (HRSA). The use of the NTDB Standard has significantly improved the reliability and fidelity of the NTDB data.

Researchers excluded pediatric patients (age 17 years or less) and geriatric patients (age 65 years or older) because of the high percentage of public insurance and low percentage of uninsured among these populations, and because of their unique responses to traumatic injury. Burn patients and patients who died in the hospital were also excluded from the study.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our public health section for the latest news on this subject. 1 Centers for Disease Control, July 2009.
2 Finkelstein, E.A., Corso, P.S., & Miller, T.R. The Incidence and Economic Burden of Injuries in the United States. USA: Oxford University Press. 2006.
3 Marquez de la Plata C, Hewlitt M, de Oliveira A, et al. Ethnic Differences in Rehabilitation Placement and Outcome After TBI. J Head Trauma Rehabil. 2007;22:113.
4 Arango-Lasprilla JC, Ketchum JM, Stevens LF, et al. Ethnicity/Racial Differences in Employment Outcomes Following Spinal Cord Injury. NeuroRehabilitation. 2009;24:37.
5 Haider AH, Efron DT, Haut ER, et al. Mortality in Adolescent Girls vs Boys Following Traumatic Shock: An Analysis of the National Pediatric Trauma Registry. Arch Surg. 2007;142:875discussion 879.
6 Haas JS, Goldman L. Acutely Injured Patients With Trauma in Massachusetts: Differences in Care and Mortality, by Insurance Status. Am J Pub Health. 1994;84:1605.
7 Haider AH, Chang DC, Efron DT, et al. Race and Insurance Status as Risk Factors for Trauma Mortality. Arch Surg. 2008;143:945.
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Massive, Consistent Changes In Inflammatory Gene Expression Seen In Trauma, Burns

Main Category: Immune System / Vaccines
Also Included In: Dermatology;  Public Health
Article Date: 09 Dec 2011 - 1:00 PST

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Serious traumatic injuries, including major burns, set off a "genomic storm" in human immune cells, altering around 80 percent of the cells' normal gene expression patterns. In a report to appear in the December Journal of Experimental Medicine, members of a nationwide research collaborative describe the initial results of their investigation into the immune system response to serious injury, findings which have overturned some longstanding assumptions.

"We have discovered there is a highly reproducible genomic response to injury that is essentially the same - no matter the patient's individual genetic background, whether the injury was caused by major trauma or serious burns, or if recovery is rapid or complicated," says Ronald G. Tompkins, MD, ScD, director of the Sumner Redstone Burn Center at Massachusetts General Hospital (MGH) and principal investigator of the study. "When this project was organized more than a decade ago, the question was raised whether responses would differ so much from person to person that no patterns would appear. It is amazing how similar our responses to injuries like serious burns or trauma actually are."

The Inflammation and Host Response to Injury consortium* was established in 2001 to investigate how the human body responds to injury and what factors set off excessive, uncontrolled inflammation that can lead to the overwhelming body-wide infection called sepsis or to multi-organ dysfunction syndrome, a life-threatening failure of vital systems. To lay the groundwork for further studies, the research team analyzed whole-genome expression patterns in white blood cells from 167 patients being treated for severe trauma at seven U.S. hospitals. Blood samples were taken within 12 hours of the injury and several times during the next 28 days. Gene expression pattern changes were tracked and compared with samples from 133 patients treated for serious burns, 37 healthy controls and four volunteers treated with a bacterial toxin that produces brief flu-like symptoms.

The genomic changes seen in the trauma and burn patients were essentially the same, with immediate increased expression of pathways involved with inflammation and with the first-response innate immune system along with simultaneous suppression of adaptive immune pathways. Over time these patterns changed only in terms of intensity and duration, which runs counter to a widely accepted theory that the initial pro-inflammatory response would be followed by an anti-inflammatory response that opens the door to complications like sepsis and organ failure. Instead the only differences between patients with and without complications were in the magnitude of gene expression changes and how long they lasted. Even the volunteers who received bacterial toxin, whose symptoms lasted for only 24 hours, had similar changes in 40 percent of the gene pathways that were altered in the seriously injured patients.

"Burn patients may take months to years to recover from their injuries, while trauma patients who are going to recover usually do so within a month. So it was entirely unexpected that gene expression patterns in burns and trauma patients changed in exactly the same directions 91 percent of the time," Tompkins explains. "Also if you consider two patients with identical injuries from a serious auto accident - a 20-year old who is ready to go home in a week and a 55-year-old who is still in the ICU and on a ventilator at the same point in time - it would be logical to think that the complications suffered by the older patient must have a genome-based difference. But it turns out that the gene expression changes are the same and the only differences is how much they change and how soon they return to normal. There are no new genes or pathways recruited to deal with those serious complications beyond those already involved in the body's basic response to serious injury.

"With this knowledge we can begin to design therapies to promote improvement in patients who would otherwise have complicated recoveries," he adds. "We also can look at whether measuring genomic changes soon after injury can help us predict which patients will recover well and which will need the maximal treatment typically delivered in ICUs, which in addition to being expensive, can sometimes be harmful." Tompkins is the Sumner M. Redstone Professor of Surgery at Harvard Medical School.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our immune system / vaccines section for the latest news on this subject. *http://www.gluegrant.org/
The nationwide collaborative program - which includes investigators from 20 academic research centers around the country - is supported by a grant from the National Institute of General Medical Sciences (NIGMS) at the National Institutes of Health. "We funded this nationwide, multidisciplinary team of researchers to explore how the body responds to life-threatening traumatic injury," said Scott Somers, PhD, of the NIGMS. "The scientists have now created a detailed picture of the genomic aspects of this response, and among their findings are some surprises about the role of inflammation that could point to new strategies for treatment."
Massachusetts General Hospital Please use one of the following formats to cite this article in your essay, paper or report:

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Massachusetts General Hospital. "Massive, Consistent Changes In Inflammatory Gene Expression Seen In Trauma, Burns." Medical News Today. MediLexicon, Intl., 9 Dec. 2011. Web.
9 Dec. 2011. APA

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