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miercuri, 14 decembrie 2011

Teen Smoking And Drinking Drops, Marijuana Consumption Rises, USA

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Main Category: Alcohol / Addiction / Illegal Drugs
Also Included In: Smoking / Quit Smoking; Pediatrics / Children's Health
Article Date: 14 Dec 2011 - 18:00 PST

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Cigarette and alcohol consumption among 8th, 10th and 12th graders (14, 16 and 18 year olds) are lower than they have ever been since certain records began in 1975, but marijuana and non-medical prescription medication usage has increased, says a new report - "Monitoring the Future" (MTF) - issued by The National Institute on Drug Abuse (NIDA). Consumption of some tobacco products did not fall, such as hookahs, smokeless tobacco and small cigars, the authors added.

In a news conference today, a NIDA spokesperson explained that more children appear to be abusing marijuana than cigarettes. Although alcohol consumption has dropped, it is still the favorite drug for children of these three ages.

Monitoring The Future is a survey which is done in classrooms and paid for by NIDA; it was carried out by researchers at the University of Michigan, Ann Arbor.

NIDA director Dr. Nora D. Volkow, said:

"That cigarette use has declined to historically low rates is welcome news, given our concerns that declines may have slowed or stalled in recent years. That said, the teen smoking rate is declining much more slowly than in years past, and we are seeing teens consume other tobacco products at high levels.
This highlights the urgency of maintaining strong prevention efforts against teen smoking and of targeting other tobacco products."

The findings for 2011 revealed that 18.7% of 12th-graders said they had smoked a cigarette during the previous four weeks, compared to 36.5% in 1997 and 21.6% in 2006. Among 8th graders, 6.1% say they are smokers, versus 21% fifteen years ago and 8.7% in 2006.

Assistant Secretary for Health, Howard K. Koh, MD, MPH, said:

"While it is good news that cigarette use has declined to historically low rates, we can and must do more to accelerate that decline. The actual decline is relatively small compared to the sharp declines we witnessed in the late nineties."

Below are some of the results from the 2011 survey for self-reported alcohol consumption: 12th graders - 63.5% said they had consumed alcohol during the previous 12-month period, versus 74.8% in 19978th graders - 26.9% said they had consumed alcohol during the previous 12-month period, versus 46.8% in 1994Binge drinking - defined as consuming at least five drinks in one sitting at any time during the previous two weeks:

- 8th graders - 6.4% said they had, compared to 8.7% in 2006
-10th graders - 14.7% said they had, compared to 19.9% in 2006
-12th graders - 21.6% said they had, compared to 25.4% in 2006

6.6% of 12th-graders say they use marijuana daily, while 36.4% say they have had it at some time during the previous twelve months - five years ago the figures stood at 5% and 31.5% respectively.

While teenage marijuana abuse grows, so does their downward perception of risk associated with the drug: 25.9% of high school seniors viewed occasional marijuana as a great risk, compared to 22.7% today.48.9% of 8th-graders viewed occasional marijuana smoking as a great risk compared to 43.4% today.Among 12-graders, 11.4% said they had used K2 (also known as spice, or synthetic marijuana) during the previous twelve months. This is the first time questions regarding K2 have been included in the survey. The authors expressed "surprise" at this figure.Gil Kerlikowske, director of National Drug Control Policy, said:

"K2 and spice are dangerous drugs that can cause serious harm. We will continue to work with the public health and safety community to respond to this emerging threat but in the meantime, parents must take action. Parents are the most powerful force in the lives of young people and we ask that all of them talk to their teens today about the serious consequences of using marijuana, K2, or spice."

Below are some more data regarding non-medical use of prescription and OTC medications In 2011, 8.1% of 12th-graders reported abusing Vicodin, an opioid painkiller, compared to 9.7% in 2009 (8.1% in 2010).In 2011, 5.9% of 10th-graders reported abusing Vicodin, compared to 7.7% in 2010.12th-graders - Adderal 6.5%, Ritalin 2.6%. Both medications used for ADHD treatment.8th graders - OTC cough medicines. Usage dropped to 2.7% in 2011, compared to 4.2% in 2006. For 12th-graders the figures were 5.3% and 6.9% respectively.Dr. Volkow said:

"To help educate teens about the dangers of prescription drug abuse, NIDA is launching an updated prescription drug section on our teen website. Teens can go to our PEERx page to find interactive videos and other tools that help them make healthy decisions and understand the risks of abusing prescription drugs. We are also encouraging teens to provide feedback on these resources through NIDA's teen blog, Sara Bellum, Twitter, Facebook, YouTube, or email."

Written by Christian Nordqvist

Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today Visit our alcohol / addiction / illegal drugs section for the latest news on this subject. Monitoring the Future
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joi, 8 decembrie 2011

Medical Marijuana Could Help Patients Reduce Pain With Opiates

Main Category: Pain / Anesthetics
Also Included In: Alcohol / Addiction / Illegal Drugs
Article Date: 08 Dec 2011 - 1:00 PST

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A UCSF study suggests patients with chronic pain may experience greater relief if their doctors add cannabinoids - the main ingredient in cannabis or medical marijuana - to an opiates-only treatment. The findings, from a small-scale study, also suggest that a combined therapy could result in reduced opiate dosages.

More than 76 million Americans suffer from chronic pain - more people than diabetes, heart disease and cancer combined, according to the National Centers for Health Statistics.

"Pain is a big problem in America and chronic pain is a reason many people utilize the health care system," said the paper's lead author, Donald Abrams, MD, professor of clinical medicine at UCSF and chief of the Hematology-Oncology Division at San Francisco General Hospital and Trauma Center (SFGH). "And chronic pain is, unfortunately, one of the problems we're least capable of managing effectively."

In a paper published this month in Clinical Pharmacology & Therapeutics, researchers examined the interaction between cannabinoids and opiates in the first human study of its kind. They found the combination of the two components reduced pain more than using opiates alone, similar to results previously found in animal studies.

Researchers studied chronic pain patients who were being treated with long-acting morphine or long-acting oxycodone. Their treatment was supplemented with controlled amounts of cannabinoids, inhaled through a vaporizer. The original focus was on whether the opiates' effectiveness increased, not on whether the cannabinoids helped reduce pain.

"The goal of the study really was to determine if inhalation of cannabis changed the level of the opiates in the bloodstream," Abrams said. "The way drugs interact, adding cannabis to the chronic dose of opiates could be expected either to increase the plasma level of the opiates or to decrease the plasma level of the opiates or to have no effect. And while we were doing that, we also asked the patients what happened to their pain."

Abrams and his colleagues studied 21 chronic pain patients in the inpatient Clinical and Transitional Science Institute's Clinical Research Center at SFGH: 10 on sustained-release morphine and 11 on oxycodone. After obtaining opiate levels from patients at the start of the study, researchers exposed them to vaporized cannabis for four consecutive days. On the fifth day, they looked again at the level of opiate in the bloodstream. Because the level of morphine was slightly lower in the patients, and the level of oxycodone was virtually unchanged, "one would expect they would have less relief of pain and what we found that was interesting was that instead of having less pain relief, patients had more pain relief," Abrams said. "So that was a little surprising."

The morphine group came in with a pain score of about 35, and on the fifth day, it decreased to 24 - a 33 percent reduction. The oxycodone group came in with an average pain score of about 44, and it reduced to 34 - a drop of 20 percent. Overall, patients showed a significant decrease in their pain.

"This preliminary study seems to imply that people may be able to get away perhaps taking lower doses of the opiates for longer periods of time if taken in conjunction with cannabis," Abrams said.

Opiates are very strong powerful pain medicines that can be highly addictive. They also can be deadly since opiates sometimes suppress the respiratory system.

As a cancer doctor, Abrams was motivated to find safe and effective treatments for chronic pain. Patients in the cannabis-opiates study experienced no major side effects such as nausea, vomiting or loss of appetite.

"What we need to do now is look at pain as the primary endpoint of a larger trial," he said. "Particularly I would be interested in looking at the effect of different strains of cannabis."

For instance, Delta 9 THC is the main psychoactive component of cannabis but cannabis contains about 70 other similar compounds with different effects. One of those is cannabidiol, or CBD. It appears to be very effective against pain and inflammation without creating the "high" created by THC.

"I think it would be interesting to do a larger study comparing high THC versus high CBD cannabis strains in association with opiates in patients with chronic pain and perhaps even having a placebo as a control," Abrams said. "That would be the next step."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our pain / anesthetics section for the latest news on this subject. Abrams is the lead author of the paper; co-authors are Paul Couey, BA, and Mary Ellen Kelly, MPH, of the UCSF Division of Hematology-Oncology at SFGH; Starley Shade, PhD, of the UCSF Center for AIDS Prevention Studies; and Neal Benowitz, MD, of the UCSF Division of Clinical Pharmacology and Experimental Therapeutics.
The study was supported by funds from the National Institutes on Drug Abuse (NIDA), a subsidiary of the National Institutes of Health (NIH).
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