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duminică, 5 august 2012

Sepsis Causes Come To Light

Death caused by infectious diseases occurs in the majority deaths, not because of the actual pathogen itself, but because of an excessive inflammatory immune response (sepsis). For example, as a result of organ damage.

Sepsis is also the second most frequent cause of death on intensive care units. Especially in patients with a severely compromised immune system, life-threatening candida fungal infections can pose a high risk of sepsis.

Leading researcher Karl Kuchler and his team at the Christian Doppler Laboratory for Infection Biology at the Max. F. Perutz Laboratories at the Vienna Biocenter Campus have now discovered the molecular causes of life-threatening inflammatory reactions that are triggered by fungal infections.

They discovered that inflammatory reaction in a candida infection is mediated by two of the immune system's highly aggressive types of phagocytes called neutrophils and inflammatory monocytes. Both phagocytes also have a high potential for collateral destruction.

Certain Interferons, i.e. the immune system's messenger substances that are excreted during fungal infections stimulate the growth of immune cell types, infecting organs and leading to sepsis.

Kuchler, said:

"We have been able to demonstrate for the first time that the targeted blockade of this immune response with inflammation-inhibiting drugs can significantly reduce candida sepsis and therefore mortality."

Kuchler used pioglitazone as an anti-inflammatory substance in the study, which is also used as an active ingredient in the treatment of type 2 diabetes.

He administered the medication in a mouse model and noted that the number and activity of neutrophils and inflammatory monocytes were significantly reduced, raising the animals' survival rate for invasive candida infections.

Kuchler continued: "The targeted blockade of excessive immune responses could therefore provide new therapeutic approaches to increase the chances of recovery from life-threatening fungal sepsis."

The world's number one cause of death is infectious diseases, and pathogenic fungi are responsible for extremely dangerous infections. Over € 6 billion are spent each year worldwide on anti-fungal medications, and the overall treatment costs for pathogenic fungi-related infectious diseases is estimated to be hundreds of billions of Euros.

Written by Grace Rattue
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today

Visit our infectious diseases / bacteria / viruses section for the latest news on this subject. "Type I Interferons Promote Fatal Immunopathology by Regulating Inflammatory Monocytes and Neutrophils during Candida Infections"
Olivia Majer, Christelle Bourgeois, Florian Zwolanek, Caroline Lassnig, Dontscho Kerjaschki, Matthias Mack, Mathias Müller, Karl Kuchler
PLoS Pathogens, August 2012, doi:10.1371/journal.ppat.1002811 Please use one of the following formats to cite this article in your essay, paper or report:

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posted by Su Su on 4 Aug 2012 at 5:12 am

Research has shown that a simple vitamin in a high dose can cure sepsis. It is also not expensive to cure using the vitamin. Wake up hospitals!

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duminică, 11 decembrie 2011

Study Sheds Light On Cancer Burden In Australia

Main Category: Cancer / Oncology
Article Date: 10 Dec 2011 - 0:00 PST

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Over the past quarter century in Australia, cancer incidence rates have increased while deaths from cancer have steadily decreased. Those are some of the findings of a recent study published early online in the Asia-Pacific Journal of Clinical Oncology.

Compared with any other disease group, cancer has the greatest overall impact on Australians' health, with one in two Australians developing cancer and one in five dying from it before the age of 85. The Australian Institute of Health and Welfare has produced an up-to-date snapshot of cancer in the country based on its cancer data holdings and regular reports, including statistics on incidence, mortality, survival, and participation in national cancer screening programs.

The study provides information from 2007, trends from 1982 to 2007, and estimations for 2010. In 2007, a total of 108,368 new cases of cancer (excluding basal and squamous cell carcinoma of the skin) and 39,884 deaths from cancer occurred in Australia. Men were most often diagnosed with prostate cancer, while women were most often diagnosed with breast cancer. Lung cancer was by far the most common cause of cancer death in both males and females.

When looking at trends, the investigators found that the number of new cancer cases diagnosed each year increased from 1982 to 2007 for both males and females, which can be explained by the aging and increasing size of the population. In females, the overall cancer incidence rate rose from 1982 through the early 1990s, after which the rate remained relatively stable. In males, the overall cancer incidence rate rose from 1982 to 1994, followed by a decline in rates until the late 1990s, when rates began to rise again. From 1982 to 2007, cancer death rates have decreased steadily for both sexes, so that the five-year survival rates for many cancers have improved markedly since the 1980s.

The report uncovered certain disparities in cancer incidence and death rates in recent years. Most notably, the overall incidence rate of cancer for Indigenous Australians was lower than that for non-indigenous Australians, while the overall death rate from cancer was higher. More diagnoses at advanced stages, less uptake of cancer treatments, and a greater number of other illnesses may contribute to the higher death rates in Indigenous Australians.

To provide a more current picture of the cancer burden in Australia, the authors extrapolated their findings to 2010, noting that about 113,700 new cases of cancer (excluding basal and squamous cell carcinoma of the skin) were expected to be diagnosed last year. Of these, 63,200 were expected to be in males and 50,500 in females. Compared with the numbers of new cancer cases diagnosed in 2007, this equates to a 2 percent increase in males and a 9 percent increase in females, mainly due to aging and growth of the population. Prostate cancer, bowel cancer, and melanoma of the skin in males, and breast cancer, bowel cancer, and melanoma of the skin in females were expected to continue to be the most commonly diagnosed cancers in 2010.

The researchers also looked at rates of participation in Australia's national screening programs for breast, cervical, and bowel cancers. From 2007 to 2008, over 1.6 million women had a screening mammogram through BreastScreen Australia, which translates to a participation rate of 55 percent for women in the target age group of 50 to 69 years. During that same time, over 3.6 million women participated in the National Cervical Screening Program, a participation rate of 61 percent for women in the target age group of 20 to 69 years. Also, almost 280,000 people (40 percent of those invited) participated in the National Bowel Cancer Screening Program in 2008. More information about these programs can be found at http://www.cancerscreening.gov.au.

Nigel Harding is Head of Communications, Media and Marketing, Australian Institute of Health and Welfare.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
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